GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

The barrier separating mucosal and systemic compartments comprises epithelial cells, annealed by tight junctions, limiting permeability. GUCY2C recently emerged as an intestinal tumor suppressor coordinating AKT1-dependent crypt-villus homeostasis. Here, the contribution of GUCY2C to barrier integri...

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Main Authors: Lin, Jieru Egeria, Snook, Adam Eugene, Li, Peng, Stoecker, Brian Arthur, Kim, Gilbert Won, Magee, Michael Sullivan, Garcia, Alex Vladimir Mejia, Valentino, Michael Anthony, Hyslop, Terry, Schulz, Stephanie, Waldman, Scott Arthur
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3284579/
https://ncbi.nlm.nih.gov/pubmed/22384056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031686
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