The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling

BACKGROUND & AIMS: Gucy2c is the intestinal cell receptor for the paracrine hormones guanylin and uroguanylin that converts GTP to cyclic (c)GMP. It functions as a tumor suppressor; its loss disrupts intestinal homeostasis and promotes tumorigenesis. We investigated the effects of Gucy2c loss on...

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Hlavní autoři: Lin, Jieru Egeria, Li, Peng, Snook, Adam Eugene, Schulz, Stephanie, Dasgupta, Abhijit, Hyslop, Terry Marie, Gibbons, Ahmara Vivian, Marszlowicz, Glen, Pitari, Giovanni Mario, Waldman, Scott Arthur
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813361/
https://ncbi.nlm.nih.gov/pubmed/19737566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.08.064
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