Colorectal Cancer Is a Paracrine Deficiency Syndrome Amenable to Oral Hormone Replacement Therapy

The most commonly lost gene products in colorectal carcinogenesis include the paracrine hormones guanylin and uroguanylin, the endogenous ligands for guanylyl cyclase C (GCC), the intestinal receptor for diarrheagenic bacterial enterotoxins. Recently, GCC‐cyclic guanosine monophosphate (GMP) signali...

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Detalhes bibliográficos
Main Authors: Li, Peng, Lin, Jieru E., Snook, Adam E., Gibbons, Ahmara V., Zuzga, David S., Schulz, Stephanie, Pitari, Giovanni M., Waldman, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Inc 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707021/
https://ncbi.nlm.nih.gov/pubmed/19727435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1752-8062.2008.00040.x
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