A Delicate Interplay of Structure, Dynamics, and Thermodynamics for Function: A High Pressure NMR Study of Outer Surface Protein A

Outer surface protein A (OspA) is a crucial protein in the infection of Borrelia burgdorferi causing Lyme disease. We studied conformational fluctuations of OspA with high-pressure (15)N/(1)H two-dimensional NMR along with high-pressure fluorescence spectroscopy. We found evidence within folded, nat...

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Detalhes bibliográficos
Main Authors: Kitahara, Ryo, Simorellis, Alana K., Hata, Kazumi, Maeno, Akihiro, Yokoyama, Shigeyuki, Koide, Shohei, Akasaka, Kazuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283806/
https://ncbi.nlm.nih.gov/pubmed/22385863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.12.010
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