IKKi is required for interleukin 17-dependent signaling associated with neutrophilia and pulmonary inflammation

Interleukin 17 (IL-17) plays a critical role in the pathogenesis of inflammatory and autoimmune diseases. Here we report that Act1, the key adaptor for IL-17R, forms a complex with IKKi upon IL-17 stimulation. Using IKKi-deficient mice, we show that IKKi was required for IL-17-induced inflammatory g...

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Detalhes bibliográficos
Main Authors: Bulek, Katarzyna, Liu, Caini, Swaidani, Shadi, Wang, Liwen, Page, Richard C., Gulen, Muhammet F., Herjan, Tomasz, Abbadi, Amina, Qian, Wen, Sun, Dongxu, Lauer, Mark, Hascall, Vincent, Misra, Saurav, Chance, Mark, Aronica, Mark, Hamilton, Thomas, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282992/
https://ncbi.nlm.nih.gov/pubmed/21822257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2080
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