Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells

Carbohydrate-responsive element-binding protein (ChREBP) is a regulator of pancreatic β-cell gene expression and an important mediator of glucotoxicity. Glucose increases the activity and nuclear localization of ChREBP by still ill-defined mechanisms. Here we reveal, using both MIN6 and primary mous...

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Hlavní autoři: Noordeen, Nafeesa A., Meur, Gargi, Rutter, Guy A., Leclerc, Isabelle
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282809/
https://ncbi.nlm.nih.gov/pubmed/22338092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1329
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