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Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
Carbohydrate-responsive element-binding protein (ChREBP) is a regulator of pancreatic β-cell gene expression and an important mediator of glucotoxicity. Glucose increases the activity and nuclear localization of ChREBP by still ill-defined mechanisms. Here we reveal, using both MIN6 and primary mous...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Diabetes Association
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3282809/ https://ncbi.nlm.nih.gov/pubmed/22338092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1329 |
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