New Binding Mode to TNF-Alpha Revealed by Ubiquitin-Based Artificial Binding Protein

A variety of approaches have been employed to generate binding proteins from non-antibody scaffolds. Utilizing a beta-sheet of the human ubiquitin for paratope creation we obtained binding proteins against tumor necrosis factor (TNF)-alpha. The bioactive form of this validated pharmacological target...

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Detalhes bibliográficos
Main Authors: Hoffmann, Andreas, Kovermann, Michael, Lilie, Hauke, Fiedler, Markus, Balbach, Jochen, Rudolph, Rainer, Pfeifer, Sven
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282696/
https://ncbi.nlm.nih.gov/pubmed/22363609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031298
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