Initiation of RNA Synthesis by the Hepatitis C Virus RNA-Dependent RNA Polymerase Is Affected by the Structure of the RNA Template

[Image: see text] The hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B is a central enzyme of the intracellular replication of the viral (+)RNA genome. Here, we studied the individual steps of NS5B-catalyzed RNA synthesis by a combination of biophysical methods, including real-time 1D (1)H...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Reich, Stefan, Kovermann, Michael, Lilie, Hauke, Knick, Paul, Geissler, René, Golbik, Ralph Peter, Balbach, Jochen, Behrens, Sven-Erik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230328/
https://ncbi.nlm.nih.gov/pubmed/25310724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5006656
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