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Mechanisms of Activity and Inhibition of the Hepatitis C Virus RNA-dependent RNA Polymerase

The RNA-dependent RNA polymerase NS5B is a key enzyme of the replication of hepatitis C virus (HCV) and a major therapeutic target. Applying a novel continuous assay with highly purified protein and a fluorescent RNA-template we provide for the first time a comprehensive mechanistic description of t...

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Autori principali: Reich, Stefan, Golbik, Ralph Peter, Geissler, René, Lilie, Hauke, Behrens, Sven-Erik
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859531/
https://ncbi.nlm.nih.gov/pubmed/20194503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082206
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