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Mechanisms of Activity and Inhibition of the Hepatitis C Virus RNA-dependent RNA Polymerase
The RNA-dependent RNA polymerase NS5B is a key enzyme of the replication of hepatitis C virus (HCV) and a major therapeutic target. Applying a novel continuous assay with highly purified protein and a fluorescent RNA-template we provide for the first time a comprehensive mechanistic description of t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859531/ https://ncbi.nlm.nih.gov/pubmed/20194503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082206 |
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