Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative.

Various antitumor drugs stabilize DNA topoisomerase II-DNA transient covalent complexes. The complexes distribution along pBR322 DNA was shown previously to depend upon the nature of the drug (Tewey et al. (1984) Science 226, 466-468). The position in pBR322 of DNA cleavage by calf DNA topoisomerase...

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Main Authors: Fossé, P, René, B, Le Bret, M, Paoletti, C, Saucier, J M
Format: Artigo
Jezik:Inglês
Izdano: 1991
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC328243/
https://ncbi.nlm.nih.gov/pubmed/1647520
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