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Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative.
Various antitumor drugs stabilize DNA topoisomerase II-DNA transient covalent complexes. The complexes distribution along pBR322 DNA was shown previously to depend upon the nature of the drug (Tewey et al. (1984) Science 226, 466-468). The position in pBR322 of DNA cleavage by calf DNA topoisomerase...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1991
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC328243/ https://ncbi.nlm.nih.gov/pubmed/1647520 |
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