Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice

In obesity, rapidly expanding adipose tissue becomes hypoxic, precipitating inflammation, fibrosis, and insulin resistance. Compensatory angiogenesis may prevent these events. Mice lacking the intracellular glucocorticoid-amplifying enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1(−/−)) have...

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Bibliografiske detaljer
Main Authors: Michailidou, Zoi, Turban, Sophie, Miller, Eileen, Zou, Xiantong, Schrader, Joerg, Ratcliffe, Peter J., Hadoke, Patrick W. F., Walker, Brian R., Iredale, John P., Morton, Nicholas M., Seckl, Jonathan R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281676/
https://ncbi.nlm.nih.gov/pubmed/22158867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.259325
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