Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway

Exposure of human populations to chronically elevated levels of ambient particulate matter air pollution < 2.5 μm in diameter (PM(2.5)) has been associated with an increase in lung cancer incidence. Over 70% of lung cancer cell lines exhibit promoter methylation of the tumor suppressor p16, an ep...

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Main Authors: Soberanes, Saul, Gonzalez, Angel, Urich, Daniela, Chiarella, Sergio E., Radigan, Kathryn A., Osornio-Vargas, Alvaro, Joseph, Joy, Kalyanaraman, Balaraman, Ridge, Karen M., Chandel, Navdeep S., Mutlu, Gökhan M., De Vizcaya-Ruiz, Andrea, Budinger, G. R. Scott
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281276/
https://ncbi.nlm.nih.gov/pubmed/22355787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00275
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