Co-Immunization with Multimeric Scaffolds and DNA Rapidly Induces Potent Autologous HIV-1 Neutralizing Antibodies and CD8(+) T Cells

To obtain proof of concept for HIV vaccines, we generated recombinant multimeric particles displaying the HIV-1 Envelope (Env) third hypervariable region (V3) as an N-terminal fusion protein on the E2 subunit of the pyruvate dehydrogenase complex of Geobacillus stearothermophilus. The E2 scaffold se...

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Detalhes bibliográficos
Main Authors: Jaworski, Juan Pablo, Krebs, Shelly J., Trovato, Maria, Kovarik, Dina N., Brower, Zachary, Sutton, William F., Waagmeester, Garrett, Sartorius, Rossella, D'Apice, Luciana, Caivano, Antonella, Doria-Rose, Nicole A., Malherbe, Delphine, Montefiori, David C., Barnett, Susan, De Berardinis, Piergiuseppe, Haigwood, Nancy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281069/
https://ncbi.nlm.nih.gov/pubmed/22359593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031464
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