HIV-1 Gag p17 presented as virus-like particles on the E2 scaffold from Geobacillus stearothermophilus induces sustained humoral and cellular immune responses in the absence of IFNγ production by CD4+ T cells

We have constructed stable virus-like particles displaying the HIV-1 Gag(p17) protein as an N-terminal fusion with an engineered protein domain from the Geobacillus stearothermophilus pyruvate dehydrogenase subunit E2. Mice immunized with the Gag(p17)-E2 60-mer scaffold particles mounted a strong an...

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Detalhes bibliográficos
Main Authors: Caivano, Antonella, Doria-Rose, Nicole A., Buelow, Benjamin, Sartorius, Rossella, Trovato, Maria, D’Apice, Luciana, Domingo, Gonzalo J., Sutton, William F., Haigwood, Nancy L., De Berardinis, Piergiuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275809/
https://ncbi.nlm.nih.gov/pubmed/20850858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.08.026
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