Defining Components of the ßcatenin Destruction Complex and Exploring Its Regulation and Mechanisms of Action during Development

BACKGROUND: A subset of signaling pathways play exceptionally important roles in embryonic and post-embryonic development, and mis-regulation of these pathways occurs in most human cancers. One such pathway is the Wnt pathway. The primary mechanism keeping Wnt signaling off in the absence of ligand...

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Autors principals: Roberts, David M., Pronobis, Mira I., Alexandre, Kelly M., Rogers, Gregory C., Poulton, John S., Schneider, Daniel E., Jung, Kuo-Chen, McKay, Daniel J., Peifer, Mark
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281067/
https://ncbi.nlm.nih.gov/pubmed/22359584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031284
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