Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

Negatively regulating signaling by targeting key effectors for ubiquitina­tion/destruction is essential for development and oncogenesis. The tumor suppressor adenomatous polyposis coli (APC), an essential negative regulator of Wnt signaling, provides a paradigm. APC mutations occur in most colon can...

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Detalhes bibliográficos
Main Authors: Roberts, David M., Pronobis, Mira I., Poulton, John S., Waldmann, Jon D., Stephenson, Elise M., Hanna, Shahnaz, Peifer, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103401/
https://ncbi.nlm.nih.gov/pubmed/21471006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-11-0871
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