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Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine
Negatively regulating key signaling pathways is critical to development and altered in cancer. Wnt signaling is kept off by the destruction complex, which is assembled around the tumor suppressors APC and Axin and targets β-catenin for destruction. Axin and APC are large proteins with many domains a...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5221518/ https://ncbi.nlm.nih.gov/pubmed/27852897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-07-0557 |
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