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Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

Wnt signaling plays key roles in embryonic development and adult stem cell homeostasis and is altered in human cancer. Signaling is turned on and off by regulating stability of the effector β-catenin (β-cat). The multiprotein destruction complex binds and phosphorylates β-cat and transfers it to the...

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Publicat a:Mol Biol Cell
Autors principals: Schaefer, Kristina N., Pronobis, Mira I., Williams, Clara E., Zhang, Shiping, Bauer, Lauren, Goldfarb, Dennis, Yan, Feng, Major, M. Ben, Peifer, Mark
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346726/
https://ncbi.nlm.nih.gov/pubmed/32129710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-11-0647
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