The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have studied the occurrence and nature of abnormalities in one of these genes, the B-cell...

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Détails bibliographiques
Auteurs principaux: Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T., van Reijmersdal, Simon V., van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M., Geurts van Kessel, Ad, van Leeuwen, Frank N., Kuiper, Roland P.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280973/
https://ncbi.nlm.nih.gov/pubmed/22359517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002533
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