The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have studied the occurrence and nature of abnormalities in one of these genes, the B-cell...

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Hlavní autoři: Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T., van Reijmersdal, Simon V., van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M., Geurts van Kessel, Ad, van Leeuwen, Frank N., Kuiper, Roland P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280973/
https://ncbi.nlm.nih.gov/pubmed/22359517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002533
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