The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have studied the occurrence and nature of abnormalities in one of these genes, the B-cell...

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Detalhes bibliográficos
Main Authors: Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T., van Reijmersdal, Simon V., van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M., Geurts van Kessel, Ad, van Leeuwen, Frank N., Kuiper, Roland P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280973/
https://ncbi.nlm.nih.gov/pubmed/22359517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002533
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