Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients

Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or negate the effects of IKZF1 deletions on prognosis....

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Publicado en:Haematologica
Autores principales: Scheijen, Blanca, Boer, Judith M., Marke, René, Tijchon, Esther, van Ingen Schenau, Dorette, Waanders, Esmé, van Emst, Liesbeth, van der Meer, Laurens T., Pieters, Rob, Escherich, Gabriele, Horstmann, Martin A., Sonneveld, Edwin, Venn, Nicola, Sutton, Rosemary, Dalla-Pozza, Luciano, Kuiper, Roland P., Hoogerbrugge, Peter M., den Boer, Monique L., van Leeuwen, Frank N.
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394950/
https://ncbi.nlm.nih.gov/pubmed/27979924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.153023
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