Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients

Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or negate the effects of IKZF1 deletions on prognosis....

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Publié dans:Haematologica
Auteurs principaux: Scheijen, Blanca, Boer, Judith M., Marke, René, Tijchon, Esther, van Ingen Schenau, Dorette, Waanders, Esmé, van Emst, Liesbeth, van der Meer, Laurens T., Pieters, Rob, Escherich, Gabriele, Horstmann, Martin A., Sonneveld, Edwin, Venn, Nicola, Sutton, Rosemary, Dalla-Pozza, Luciano, Kuiper, Roland P., Hoogerbrugge, Peter M., den Boer, Monique L., van Leeuwen, Frank N.
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2017
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394950/
https://ncbi.nlm.nih.gov/pubmed/27979924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.153023
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