The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution.

Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have studied the occurrence and nature of abnormalities in one of these genes, the B-cell...

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Main Authors: Esmé Waanders, Blanca Scheijen, Laurens T van der Meer, Simon V van Reijmersdal, Liesbeth van Emst, Yvet Kroeze, Edwin Sonneveld, Peter M Hoogerbrugge, Ad Geurts van Kessel, Frank N van Leeuwen, Roland P Kuiper
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS Genetics
Acesso em linha:http://europepmc.org/articles/PMC3280973?pdf=render
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