Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

Cytotoxic chemotherapy targets elements common to all nucleated human cells, such as DNA and microtubules, yet it selectively kills tumor cells. Here we show that clinical response to these drugs correlates with, and may be partially governed by, the pre-treatment proximity of tumor cell mitochondri...

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Hlavní autoři: Chonghaile, Triona Ni, Sarosiek, Kristopher A., Vo, Thanh-Trang, Ryan, Jeremy A., Tammareddi, Anupama, Moore, Victoria Del Gaizo, Deng, Jing, Anderson, Ken, Richardson, Paul, Tai, Yu-Tzu, Mitsiades, Constantine S., Matulonis, Ursula A., Drapkin, Ronny, Stone, Richard, DeAngelo, Daniel J., McConkey, David J., Sallan, Stephen E., Silverman, Lewis, Hirsch, Michelle S., Carrasco, Daniel Ruben, Letai, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280949/
https://ncbi.nlm.nih.gov/pubmed/22033517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1206727
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