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Acid-Triggered Transformation of Diortho Ester Phosphocholine Liposome

[Image: see text] The use of pH-sensitive liposomes for acid-triggered site specific drug delivery is one of the more promising approaches to improve the therapeutic index of drugs. Here, we report the synthesis, assembly, and hydrolysis of the first ortho ester phosphocholine (OEPC). The acid hydro...

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Autors principals: Huang, Zhaohua, Guo, Xin, Li, Weijun, MacKay, J. Andrew, Szoka, Francis C.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280609/
https://ncbi.nlm.nih.gov/pubmed/16390121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja057024w
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