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Enhanced delivery of α-glucosidase for Pompe disease by ICAM-1-targeted nanocarriers: comparative performance of a strategy for three distinct lysosomal storage disorders

Enzyme replacement therapies for lysosomal storage disorders are often hindered by suboptimal biodistribution of recombinant enzymes after systemic injection. This is the case for Pompe disease caused by acid α-glucosidase (GAA) deficiency, leading to excess glycogen storage through the body, mainly...

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Bibliografiska uppgifter
Huvudupphovsmän: Hsu, Janet, Northrup, Laura, Bhowmick, Tridib, Muro, Silvia
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279604/
https://ncbi.nlm.nih.gov/pubmed/21906578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2011.08.014
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