C-Terminal Fluorescent Labeling Impairs Functionality of DNA Mismatch Repair Proteins

The human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated. Germline mutations in MMR genes are responsible for the development of the hereditary form of colorectal cancer called Lynch s...

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Bibliographic Details
Main Authors: Brieger, Angela, Plotz, Guido, Hinrichsen, Inga, Passmann, Sandra, Adam, Ronja, Zeuzem, Stefan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279419/
https://ncbi.nlm.nih.gov/pubmed/22348133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031863
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