Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

BACKGROUND: Miltefosine (MF) is the first oral compound used in the chemotherapy against leishmaniasis. Since the mechanism of action of this drug and the targets of MF in Leishmania are unclear, we generated in a step-by-step manner Leishmania major promastigote mutants highly resistant to MF. Two...

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Bibliographic Details
Main Authors: Coelho, Adriano C., Boisvert, Sébastien, Mukherjee, Angana, Leprohon, Philippe, Corbeil, Jacques, Ouellette, Marc
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279362/
https://ncbi.nlm.nih.gov/pubmed/22348164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001512
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