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Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

BACKGROUND: Miltefosine (MF) is the first oral compound used in the chemotherapy against leishmaniasis. Since the mechanism of action of this drug and the targets of MF in Leishmania are unclear, we generated in a step-by-step manner Leishmania major promastigote mutants highly resistant to MF. Two...

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Detalhes bibliográficos
Main Authors: Coelho, Adriano C., Boisvert, Sébastien, Mukherjee, Angana, Leprohon, Philippe, Corbeil, Jacques, Ouellette, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279362/
https://ncbi.nlm.nih.gov/pubmed/22348164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001512
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