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Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania
Current genome-wide screens allow system-wide study of drug resistance but detecting small nucleotide variants (SNVs) is challenging. Here, we use chemical mutagenesis, drug selection and next generation sequencing to characterize miltefosine and paromomycin resistant clones of the parasite Leishman...
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| Yayımlandı: | Nat Commun |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6901541/ https://ncbi.nlm.nih.gov/pubmed/31819054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13344-6 |
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