Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Current genome-wide screens allow system-wide study of drug resistance but detecting small nucleotide variants (SNVs) is challenging. Here, we use chemical mutagenesis, drug selection and next generation sequencing to characterize miltefosine and paromomycin resistant clones of the parasite Leishman...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Bhattacharya, Arijit, Leprohon, Philippe, Bigot, Sophia, Padmanabhan, Prasad Kottayil, Mukherjee, Angana, Roy, Gaétan, Gingras, Hélène, Mestdagh, Anais, Papadopoulou, Barbara, Ouellette, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901541/
https://ncbi.nlm.nih.gov/pubmed/31819054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13344-6
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