Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Current genome-wide screens allow system-wide study of drug resistance but detecting small nucleotide variants (SNVs) is challenging. Here, we use chemical mutagenesis, drug selection and next generation sequencing to characterize miltefosine and paromomycin resistant clones of the parasite Leishman...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Bhattacharya, Arijit, Leprohon, Philippe, Bigot, Sophia, Padmanabhan, Prasad Kottayil, Mukherjee, Angana, Roy, Gaétan, Gingras, Hélène, Mestdagh, Anais, Papadopoulou, Barbara, Ouellette, Marc
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901541/
https://ncbi.nlm.nih.gov/pubmed/31819054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13344-6
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