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Use of Cre-adenovirus and CAR transgenic mice for efficient deletion of genes in post-thymic T cells

Conditional gene deletion using lineage-specific transgenic expression of Cre has been useful for defining the role of specific gene products in mice in vivo. However, this technology has had limitations for studies of peripheral T cell biology, since the T-lineage promoters commonly used are active...

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Hlavní autoři: Zha, Yuanyuan, Shah, Ramila, Locke, Frederick, Wong, Austin, Gajewski, Thomas F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278801/
https://ncbi.nlm.nih.gov/pubmed/18177887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2007.11.013
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