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An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells
Cbl family ubiquitin ligases act as key negative regulators of TCR signaling. Knockout mice lacking Cbl-b and c-Cbl show augmented T cell activation and CD28-independent IL-2 production. In order to study Cbl function directly in post-thymic T cells, a DN Cbl adenovirus was generated for transductio...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286639/ https://ncbi.nlm.nih.gov/pubmed/17897636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2007.07.006 |
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