Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

Apoptosis of articular chondrocytes is associated with the pathogenesis of osteoarthritis (OA). Recently, we demonstrated that hypoxia-inducible factor (HIF)-2α, encoded by Epas1, causes OA cartilage destruction by regulating the expression of various matrix-degrading enzymes. Here, we investigated...

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Bibliografiske detaljer
Main Authors: Ryu, J-H, Shin, Y, Huh, Y H, Yang, S, Chun, C-H, Chun, J-S
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278727/
https://ncbi.nlm.nih.gov/pubmed/21869830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.111
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