Low-density lipoprotein receptor–related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction

INTRODUCTION: Wnt ligands bind to low-density lipoprotein receptor–related protein (LRP) 5 or 6, triggering a cascade of downstream events that include β-catenin signaling. Here we explored the roles of LRP5 in interleukin 1β (IL-1β)- or Wnt-mediated osteoarthritic (OA) cartilage destruction in mice...

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Main Authors: Shin, Youngnim, Huh, Yun Hyun, Kim, Kieun, Kim, Suyeon, Park, Ka Hyon, Koh, Jeong-Tae, Chun, Jang-Soo, Ryu, Je-Hwang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978879/
https://ncbi.nlm.nih.gov/pubmed/24479426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4466
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