Anti-ischemic effects of multivalent dendrimeric A(3) adenosine receptor agonists in cultured cardiomyocytes and in the isolated rat heart

Adenosine released during myocardial ischemia mediates cardioprotective preconditioning. Multivalent drugs covalently bound to nanocarriers may differ greatly in chemical and biological properties from the corresponding monomeric agents. Here, we conjugated chemically functionalized nucleosides to p...

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Hlavní autoři: Chanyshev, Bella, Shainberg, Asher, Isak, Ahuva, Litinsky, Alexandra, Chepurko, Yelena, Tosh, Dilip K., Phan, Khai, Gao, Zhan-Guo, Hochhauser, Edith, Jacobson, Kenneth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278557/
https://ncbi.nlm.nih.gov/pubmed/22154845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2011.11.013
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