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Trimer hydroxylated quinone (IIIHyQ) derived from apocynin targets cysteine residues of p47(phox) preventing the activation of human vascular NADPH oxidase

Enzymatic derived oligophenols from apocynin can be effective inhibitors of human vascular NADPH oxidase. An isolated IIIHyQ has been shown to inhibit endothelial NADPH oxidase with an IC(50) ~30 nM. In vitro studies demonstrated that IIIHyQ is capable on disrupting the interaction between p47(phox)...

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Detalhes bibliográficos
Main Authors: Mora-Pale, Mauricio, Joon-Kwon, Seok, Linhardt, Robert J., Dordick, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278529/
https://ncbi.nlm.nih.gov/pubmed/22240153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.12.015
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