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Trimer hydroxylated quinone (IIIHyQ) derived from apocynin targets cysteine residues of p47(phox) preventing the activation of human vascular NADPH oxidase
Enzymatic derived oligophenols from apocynin can be effective inhibitors of human vascular NADPH oxidase. An isolated IIIHyQ has been shown to inhibit endothelial NADPH oxidase with an IC(50) ~30 nM. In vitro studies demonstrated that IIIHyQ is capable on disrupting the interaction between p47(phox)...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3278529/ https://ncbi.nlm.nih.gov/pubmed/22240153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.12.015 |
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