Fluoride ion catalyzed alkylation of nucleic acid derivatives using trialkyl phosphates, dialkyl sulfates and alkyl methanesulfonates.

Trimethyl phosphate, dimethyl and diethyl sulfate and methyl and ethyl methanesulfonate all give high yields of alkylation on purines and pyrimidines in the presence of tetrabutylammonium fluoride. Trimethyl phosphate produces near quantitative yields of diesters of nucleic acids but gives virtually...

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Hauptverfasser: Ogilvie, K K, Beaucage, S L, Gillen, M F, Entwistle, D W
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1979
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC327849/
https://ncbi.nlm.nih.gov/pubmed/223127
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