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Phase I trial of ATRA-IV and depakote in patients with advanced solid tumor malignancies

Retinoic acid derivatives have shown their greatest benefit in acute promyelocytic leukemia, but have also demonstrated pre-clinical anti-cancer effects in some solid tumors. Histone deacetylase inhibitors, by upregulating gene expression, are able to limit cancer cell proliferation and induce apopt...

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Bibliografiska uppgifter
Huvudupphovsmän: David, Kevin A, Mongan, Nigel P, Smith, Christopher, Gudas, Lorraine J, Nanus, David M
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277777/
https://ncbi.nlm.nih.gov/pubmed/20200483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.9.9.11436
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