Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies

PURPOSE: To determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of tanespimycin when given in combination with bortezomib. EXPERIMENTAL DESIGN: Phase I dose-escalating trial using a standard cohort “3+3” design performed in patients with advanced solid tumo...

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Bibliografiske detaljer
Main Authors: Schenk, Erin, Wahner Hendrickson, Andrea E., Northfelt, Donald, Toft, David O., Ames, Matthew M., Menefee, Michael, Satele, Daniel, Qin, Rui, Erlichman, Charles
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929968/
https://ncbi.nlm.nih.gov/pubmed/23543109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-013-9946-7
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