Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice

Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant all...

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Main Authors: Kane, Kelly L., Longo-Guess, Chantal M., Gagnon, Leona H., Ding, Dalian, Salvi, Richard J., Johnson, Kenneth R.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277672/
https://ncbi.nlm.nih.gov/pubmed/22138310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2011.11.007
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