Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins

The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins(1–4). Virulence is dependent on the autoactivation of a toxin cysteine protease(5–9), which is promoted by the allosteric cofactor inositol hexakisphospha...

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Detalhes bibliográficos
Main Authors: Savidge, Tor C, Urvil, Petri, Oezguen, Numan, Ali, Kausar, Choudhury, Aproteem, Acharya, Vinay, Pinchuk, Irina, Torres, Alfredo G, English, Robert D, Wiktorowicz, John E, Loeffelholz, Michael, Kumar, Raj, Shi, Lianfa, Nie, Weijia, Braun, Werner, Herman, Bo, Hausladen, Alfred, Feng, Hanping, Stamler, Jonathan S, Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277400/
https://ncbi.nlm.nih.gov/pubmed/21857653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2405
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