Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins

The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins(1–4). Virulence is dependent on the autoactivation of a toxin cysteine protease(5–9), which is promoted by the allosteric cofactor inositol hexakisphospha...

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Hauptverfasser: Savidge, Tor C, Urvil, Petri, Oezguen, Numan, Ali, Kausar, Choudhury, Aproteem, Acharya, Vinay, Pinchuk, Irina, Torres, Alfredo G, English, Robert D, Wiktorowicz, John E, Loeffelholz, Michael, Kumar, Raj, Shi, Lianfa, Nie, Weijia, Braun, Werner, Herman, Bo, Hausladen, Alfred, Feng, Hanping, Stamler, Jonathan S, Pothoulakis, Charalabos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277400/
https://ncbi.nlm.nih.gov/pubmed/21857653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2405
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