Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins

The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins(1–4). Virulence is dependent on the autoactivation of a toxin cysteine protease(5–9), which is promoted by the allosteric cofactor inositol hexakisphospha...

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Bibliografiske detaljer
Main Authors: Savidge, Tor C, Urvil, Petri, Oezguen, Numan, Ali, Kausar, Choudhury, Aproteem, Acharya, Vinay, Pinchuk, Irina, Torres, Alfredo G, English, Robert D, Wiktorowicz, John E, Loeffelholz, Michael, Kumar, Raj, Shi, Lianfa, Nie, Weijia, Braun, Werner, Herman, Bo, Hausladen, Alfred, Feng, Hanping, Stamler, Jonathan S, Pothoulakis, Charalabos
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277400/
https://ncbi.nlm.nih.gov/pubmed/21857653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2405
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