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Antitumor Efficacy of 34.5ENVE: A Transcriptionally Retargeted and “Vstat120”-expressing Oncolytic Virus

Here, we describe the construction and testing of a novel herpes simplex virus type 1 (HSV-1) derived oncolytic virus (OV): 34.5ENVE (viral ICP34.5 Expressed by Nestin promotor and Vstat120 Expressing), for the treatment of cancer. This virus showed significant glioma-specific killing and antiangiog...

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Autors principals: Yoo, Ji Young, Haseley, Amy, Bratasz, Anna, Chiocca, E Antonio, Zhang, Jianying, Powell, Kimerly, Kaur, Balveen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277242/
https://ncbi.nlm.nih.gov/pubmed/22031239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.208
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