Copper chelation enhances anti-tumor efficacy and systemic delivery of oncolytic HSV

PURPOSE: Copper in serum supports angiogenesis and inhibits replication of wild type HSV-1. Copper chelation is currently being investigated as an anti-angiogenic and anti-neoplastic agent in patients diagnosed with cancer. Herpes simplex virus derived oncolytic viruses (oHSVs) are being evaluated f...

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Detalhes bibliográficos
Main Authors: Yoo, Ji Young, Pradarelli, Jason, Haseley, Amy, Wojton, Jeffrey, Kaka, Azeem, Bratasz, Anna, Alvarez-Breckenridge, Christopher, Yu, Jun, Powell, Kimerly, Mazar, Andrew, Teknos, Theodoros N, Chiocca, E. Antonio, Glorioso, Joseph C., Old, Matthew, Kaur, Balveen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784008/
https://ncbi.nlm.nih.gov/pubmed/22753591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0697
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