PCSK9 LNA Antisense Oligonucleotides Induce Sustained Reduction of LDL Cholesterol in Nonhuman Primates

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a therapeutic target for the reduction of low-density lipoprotein cholesterol (LDL-C). PCSK9 increases the degradation of the LDL receptor, resulting in high LDL-C in individuals with high PCSK9 activity. Here, we show that two loc...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Lindholm, Marie W, Elmén, Joacim, Fisker, Niels, Hansen, Henrik F, Persson, Robert, Møller, Marianne R, Rosenbohm, Christoph, Ørum, Henrik, Straarup, Ellen M, Koch, Troels
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
Предметы:
Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277239/
https://ncbi.nlm.nih.gov/pubmed/22108858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.260
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы