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Human SIRT6 promotes DNA-end resection through CtIP deacetylation
SIRT6 belongs to the sirtuin family of protein lysine deacetylases (KDACs) that regulates ageing and genome stability. Here, we report a role for human SIRT6 in promoting DNA-end resection, a crucial step in DNA double-strand break (DSB) repair by homologous recombination (HR). SIRT6 depletion impai...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276839/ https://ncbi.nlm.nih.gov/pubmed/20829486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1192049 |
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